Atlas of Genetics and Cytogenetics in Oncology and Haematology PTPN 6 ( protein tyrosine phosphatase , non - receptor type 6 )
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چکیده
The human PTPN6 gene is divided in 17 exons spanning a length of 14740 bp. A notable feature of the PTPN6 gene is that it has two promoter regions. Whereas the distal promoter, P1, located upstream of the very short exon 1 (also known as exon 1a) is active in epithelial cells, the proximal promoter P2 that initiates gene transcription from exon 2 (known as exon 1b), is utilized by the hematopoietic cells. The function of P1 promoter has been partially elucidated, while the structure and regulatory mechanism of the P2 promoter remain essentially unknown. Recent findings, characterized the hematopoietic cellspecific P2 promoter of PTPN6 gene as well as identified the PU.1 transcription factor as the activator of the P2 promoter. Transcription
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تاریخ انتشار 2013